Issue 23, 2012
From the journal:

Chemical Communications

A new practical approach towards the synthesis of unsymmetric and symmetric 1,10-phenanthroline derivatives at room temperature†

Yongfeng Cheng,ab   Xuesong Han,a   Huangche Ouyanga  and  Yu Rao*a  

* Corresponding authors

a Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China
E-mail: yrao@mail.tsinghua.edu.cn

b Tianjin University of Traditional Chinese Medicine, Tianjin, China

Abstract

An efficient method towards synthesis of 1,10-phenanthrolines is described. Through Lewis acid-catalyzed annulation reaction between 3-ethoxycyclobutanones and 8-aminoquinolines, a variety of unsymmetric and symmetric 1,10-phenanthroline derivatives were readily prepared with high regioselectivity at room temperature.

Graphical abstract: A new practical approach towards the synthesis of unsymmetric and symmetric 1,10-phenanthroline derivatives at room temperature

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Article information

DOI
https://doi.org/10.1039/C2CC17208A
Article type
Communication
Submitted
19 Nov 2011
Accepted
19 Jan 2012
First published
20 Jan 2012

Chem. Commun., 2012,48, 2906-2908

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A new practical approach towards the synthesis of unsymmetric and symmetric 1,10-phenanthroline derivatives at room temperature

Y. Cheng, X. Han, H. Ouyang and Y. Rao, Chem. Commun., 2012, 48, 2906 DOI: 10.1039/C2CC17208A

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