Issue 8, 2011
From the journal:

Soft Matter

Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation†

Hamilton Kakwere,a   Richard J. Payne,b   Katrina A. Jolliffe*b  and  Sébastien Perrier*a  

* Corresponding authors

a Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Building F11, NSW, Australia
E-mail: sebastien.perrier@sydney.edu.au

b School of Chemistry, The University of Sydney, Building F11, NSW, Australia
E-mail: kate.jolliffe@sydney.edu.au

Abstract

Water soluble poly(hydroxyethyl acrylate) [P(HEA)] polymers were successfully conjugated to an azide functionalized β-sheet forming peptide (P11-2) to form macromolecular chimeras using Cu(I) catalyzed azide–alkyne cycloaddition (‘click’) chemistry. We found that the β-sheet formation and hence fibrillization tendency of P11-2 was severely diminished by P(HEA) conjugation. Moreover chimeras were observed to inhibit fibrillization when added to a pure β-sheet forming peptide.

Graphical abstract: Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

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Article information

DOI
https://doi.org/10.1039/C0SM01237H
Article type
Communication
Submitted
31 Oct 2010
Accepted
24 Feb 2011
First published
11 Mar 2011

Soft Matter, 2011,7, 3754-3757

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Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

H. Kakwere, R. J. Payne, K. A. Jolliffe and S. Perrier, Soft Matter, 2011, 7, 3754 DOI: 10.1039/C0SM01237H

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