Issue 3, 2011
From the journal:

Soft Matter

Mobility of fluorescently labeled polymer micelles in living cells

Feng Li,ab   Adrie H. Westphal,c   Antonius T. M. Marcelis,*a   Ernst J. R. Sudhölter,d   Martien A. Cohen Stuartb  and  Frans A. M. Leermakersb  

* Corresponding authors

a Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, Wageningen, The Netherlands
E-mail: ton.marcelis@wur.nl

b Laboratory of Physical Chemistry, Wageningen University, Dreijenplein 6, Wageningen, The Netherlands

c Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, Wageningen, The Netherlands

d Laboratory of Nano-organic chemistry, Department of Chemical Engineering, Delft University of Technology, Julianalaan 136, Delft, The Netherlands

Abstract

Stabilized fluorescent polymeric micelles were made that are spontaneously taken up into the cytoplasm of human cells. The mobility of these micelles in living cells was probed on a molecular level for the first time with FCS. Importantly, the present micelles do not interact with proteins, membranes or cellular organelles. This system provides a new nanotechnological tool which is biocompatible, versatile and easy to use, especially since after further chemical modification, they could be targeted to specific subcellular locations.

Graphical abstract: Mobility of fluorescently labeled polymer micelles in living cells

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Article information

DOI
https://doi.org/10.1039/C0SM00835D
Article type
Paper
Submitted
18 Aug 2010
Accepted
27 Nov 2010
First published
20 Dec 2010

Soft Matter, 2011,7, 1214-1218

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Mobility of fluorescently labeled polymer micelles in living cells

F. Li, A. H. Westphal, A. T. M. Marcelis, E. J. R. Sudhölter, M. A. Cohen Stuart and F. A. M. Leermakers, Soft Matter, 2011, 7, 1214 DOI: 10.1039/C0SM00835D

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