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Issue 13, 2011
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Design and synthesis of bile acidpeptide conjugates linked viatriazole moiety

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Abstract

A conjugation of bile acids with peptidesviaCu(I)-catalyzed click chemistry has been described. Novel bile acidpeptide conjugates linked via a 1,2,3-triazole moiety based on cholic, deoxycholic and lithocholic acid derivatives were synthesized using Cu(I)-catalyzed 1,3-dipolar cycloaddition (“click” reaction). It was shown that up to three peptide fragments can be attached to a central steroid core, thus forming complex three-dimensional polyconjugate structures, which can find important applications in biochemistry, medicinal chemistry, and coordination chemistry.

Graphical abstract: Design and synthesis of bile acid–peptide conjugates linked viatriazole moiety

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Publication details

The article was received on 16 Dec 2010, accepted on 11 Apr 2011 and first published on 12 Apr 2011


Article type: Paper
DOI: 10.1039/C0OB01188F
Org. Biomol. Chem., 2011,9, 4921-4926

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    Design and synthesis of bile acidpeptide conjugates linked viatriazole moiety

    N. V. Sokolova, G. V. Latyshev, N. V. Lukashev and V. G. Nenajdenko, Org. Biomol. Chem., 2011, 9, 4921
    DOI: 10.1039/C0OB01188F

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