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Issue 13, 2011
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Synthesis of pyrrole and indole quinoxalinone and oxazinone derivatives by intramolecular copper-catalyzed reactions

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Abstract

Intramolecular N-arylation of pyrrole and indole carboxamides and carboxylates linked with a pendant haloarene by Cu-catalyzed reactions to synthesize pyrrole and indole quinoxalinone and oxazinone derivatives is reported. The ring closure reactions were carried out by conventional heating and MW irradiation. The use of conventional heating affords moderate to good yields of the quinoxalinone and oxazinone derivatives (34–72%), while by using MW heating the best results are obtained (41–99%).

Graphical abstract: Synthesis of pyrrole and indole quinoxalinone and oxazinone derivatives by intramolecular copper-catalyzed reactions

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Submitted
18 Feb 2011
Accepted
31 Mar 2011
First published
31 Mar 2011

Org. Biomol. Chem., 2011,9, 4927-4935
Article type
Paper

Synthesis of pyrrole and indole quinoxalinone and oxazinone derivatives by intramolecular copper-catalyzed reactions

V. A. Vaillard, R. A. Rossi and S. E. Martín, Org. Biomol. Chem., 2011, 9, 4927
DOI: 10.1039/C1OB05269A

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