Issue 1, 2011
From the journal:

Organic & Biomolecular Chemistry

FeCl3-promoted alkylation of indoles by enamides†

Tianmin Niu,a   Lehao Huang,a   Tianxing Wua  and  Yuhong Zhang*a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China
E-mail: yhzhang@zju.edu.cn
Fax: 0086-571-87953244
Tel: 0086-571-87952723

Abstract

An efficient iron-promoted alkylation of indoles with enamides has been accomplished under mild reaction conditions. The reaction proceeded with remarkable regioselectivity leading exclusively to substitution by indoles at α-position of enamides.

Graphical abstract: FeCl3-promoted alkylation of indoles by enamides

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Article information

DOI
https://doi.org/10.1039/C0OB00709A
Article type
Paper
Submitted
13 Sep 2010
Accepted
07 Oct 2010
First published
17 Nov 2010

Org. Biomol. Chem., 2011,9, 273-277

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FeCl3-promoted alkylation of indoles by enamides

T. Niu, L. Huang, T. Wu and Y. Zhang, Org. Biomol. Chem., 2011, 9, 273 DOI: 10.1039/C0OB00709A

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