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Issue 1, 2011
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Synthesis of dysideaproline E using organocatalysis

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Abstract

(S)-4,4-Dichloro-3-methylbutanoic acid was prepared in 51% overall yield from commercially available starting materials using an organocatalytic transfer hydrogenation to 4,4-dichloro-3-methylbut-2-enal in the key step. The (S)-dichloro acid was used as an intermediate in the first total synthesis of dysideaproline E and a diastereomer confirming the structure of the natural product.

Graphical abstract: Synthesis of dysideaproline E using organocatalysis

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Publication details

The article was received on 23 Aug 2010, accepted on 05 Oct 2010 and first published on 15 Nov 2010


Article type: Paper
DOI: 10.1039/C0OB00617C
Org. Biomol. Chem., 2011,9, 265-272

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    Synthesis of dysideaproline E using organocatalysis

    E. Owusu-Ansah, A. C. Durow, J. R. Harding, A. C. Jordan, S. J. O'Connell and C. L. Willis, Org. Biomol. Chem., 2011, 9, 265
    DOI: 10.1039/C0OB00617C

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