Issue 7, 2011

Anti-colorectal cancer activity of an organometallic osmium areneazopyridine complex

Abstract

This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(η6-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6, is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.

Graphical abstract: Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

Supplementary files

Article information

Article type
Concise Article
Submitted
15 Mar 2011
Accepted
10 Apr 2011
First published
19 May 2011

Med. Chem. Commun., 2011,2, 666-668

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

S. D. Shnyder, Y. Fu, A. Habtemariam, S. H. van Rijt, P. A. Cooper, P. M. Loadman and P. J. Sadler, Med. Chem. Commun., 2011, 2, 666 DOI: 10.1039/C1MD00075F

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