Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space†
Abstract
Utilising ‘beyond rule of five’ chemical space is becoming increasingly important in
* Corresponding authors
a
Worldwide Medicinal Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Kent, UK
E-mail:
david.millan@pfizer.com
Utilising ‘beyond rule of five’ chemical space is becoming increasingly important in
The article was received on 31 Mar 2011, accepted on 22 Apr 2011 and first published on 20 May 2011
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