Issue 4, 2011

Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

Abstract

A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure–activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF3 group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities.

Graphical abstract: Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

Supplementary files

Article information

Article type
Concise Article
Submitted
27 Nov 2010
Accepted
27 Jan 2011
First published
28 Feb 2011

Med. Chem. Commun., 2011,2, 315-320

Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

G. Chen, H. Xia, Y. Cai, D. Ma, J. Yuan and C. Yuan, Med. Chem. Commun., 2011, 2, 315 DOI: 10.1039/C0MD00236D

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