Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 4, 2011
Previous Article Next Article

Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

Author affiliations

Abstract

A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure–activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF3 group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities.

Graphical abstract: Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Nov 2010, accepted on 27 Jan 2011 and first published on 28 Feb 2011


Article type: Concise Article
DOI: 10.1039/C0MD00236D
Citation: Med. Chem. Commun., 2011,2, 315-320

  •   Request permissions

    Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

    G. Chen, H. Xia, Y. Cai, D. Ma, J. Yuan and C. Yuan, Med. Chem. Commun., 2011, 2, 315
    DOI: 10.1039/C0MD00236D

Search articles by author

Spotlight

Advertisements