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Issue 4, 2011
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Water soluble flavonolprodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart

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Abstract

Phosphate and hemiadipate derivatives of cardioprotective flavonols are water soluble prodrugs that release superoxide scavenging and vasorelaxant parent drugs. These prodrugs protected against ischaemia/reperfusion injury in two distinct animal models, rat hindlimb and sheep heart, and are thus promising small molecule therapeutics for cardiovascular disease.

Graphical abstract: Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart

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Supplementary files

Article information


Submitted
29 Nov 2010
Accepted
06 Feb 2011
First published
01 Mar 2011

Med. Chem. Commun., 2011,2, 321-324
Article type
Concise Article

Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart

S. J. Williams, C. J. Thomas, M. Boujaoude, C. T. Gannon, S. D. Zanatta, B. Jarrott, C. N. May and O. L. Woodman, Med. Chem. Commun., 2011, 2, 321
DOI: 10.1039/C0MD00240B

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