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Issue 4, 2011
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Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

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Abstract

The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.

Graphical abstract: Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

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The article was received on 26 Nov 2010, accepted on 16 Jan 2011 and first published on 11 Feb 2011


Article type: Concise Article
DOI: 10.1039/C0MD00235F
Med. Chem. Commun., 2011,2, 270-273

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    Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

    J. Jin, W. S. Lee, K. M. Joo, K. K. Maiti, G. Biswas, W. Kim, K. Kim, S. J. Lee, K. Kim, D. Nam and S. Chung, Med. Chem. Commun., 2011, 2, 270
    DOI: 10.1039/C0MD00235F

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