Issue 4, 2011
From the journal:

MedChemComm

Conformational effects on potency of thioimidazoles and dihydrothiazolines

Roland Selig,*a   Verena Schattel,a   Marcia Goettert,a   Dieter Schollmeyer,b   Wolfgang Albrechtc  and  Stefan Laufer*a  

* Corresponding authors

a Department of Medicinal Chemistry, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, Tuebingen, Germany
E-mail: stefan.laufer@uni-tuebingen.de

b Department of Organic Chemistry, University Mainz, Duesbergweg 10-14, Mainz, Germany

c c-a-i- r biosciences GmbH, Paul-Ehrlich-Strasse 15, Tuebingen, Germany

Abstract

We investigated the effect of steric restriction and hindrance on inhibitors directed against the biological activity of p38α MAP kinase. The structural reduction of the early lead compound SKF86002 into three structural classes of optimized SKF86002-like inhibitors produced a strong effect on inhibitory potency. This effect was investigated by conformational analysis and docking experiments.

Graphical abstract: Conformational effects on potency of thioimidazoles and dihydrothiazolines

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C0MD00228C
Article type
Concise Article
Submitted
19 Nov 2010
Accepted
05 Jan 2011
First published
27 Jan 2011

Med. Chem. Commun., 2011,2, 261-269

Permissions

Request permissions

Conformational effects on potency of thioimidazoles and dihydrothiazolines

R. Selig, V. Schattel, M. Goettert, D. Schollmeyer, W. Albrecht and S. Laufer, Med. Chem. Commun., 2011, 2, 261 DOI: 10.1039/C0MD00228C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements