Issue 4, 2011

An efficient synthesis of dihydrothiophene ureidoformamides by domino reactions of 1,3-thiazolidinedione under catalyst-free conditions

Abstract

An efficient synthesis of dihydrothiophene ureidoformamides by the domino reactions of aldehydes, malononitrile, amines and 1,3-thiazolidinedione in PEG 400/H2O is studied. The reaction is free of catalysts and toxic solvents, of shorter reaction time and with ease of the product isolation, making it more environmentally friendly and suitable for large-scale operations.

Graphical abstract: An efficient synthesis of dihydrothiophene ureidoformamides by domino reactions of 1,3-thiazolidinedione under catalyst-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
06 Dec 2010
Accepted
24 Jan 2011
First published
28 Feb 2011

Green Chem., 2011,13, 998-1003

An efficient synthesis of dihydrothiophene ureidoformamides by domino reactions of 1,3-thiazolidinedione under catalyst-free conditions

G. Lu, L. Zeng and C. Cai, Green Chem., 2011, 13, 998 DOI: 10.1039/C0GC00884B

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