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Issue 43, 2017
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Digitally encoded silica microparticles for multiplexed nucleic acid detection

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Abstract

A robust high throughput suspension array was proposed to analyze biomolecules. To exploit its capacity for nucleic acid detection, we designed a multiplex nested asymmetric PCR (MNAS PCR) that can produce single stranded DNA (ssDNA) efficiently without complicated optimization. Multiplexed HPV genotyping was demonstrated with high selectivity, high sensitivity and rapid hybridization within 20 minutes.

Graphical abstract: Digitally encoded silica microparticles for multiplexed nucleic acid detection

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Supplementary files

Article information


Submitted
15 Mar 2017
Accepted
08 May 2017
First published
16 May 2017

Chem. Commun., 2017,53, 5866-5869
Article type
Communication

Digitally encoded silica microparticles for multiplexed nucleic acid detection

W. Xu, C. Chen, X. Ma, L. Yuan, S. Liu, K. Zheng and J. Li, Chem. Commun., 2017, 53, 5866
DOI: 10.1039/C7CC01974B

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