Issue 38, 2011

Intrastrand locks increase duplex stability and base pairing selectivity

Abstract

Oligodeoxynucleotide probes with disulfide locks between neighboring nucleobases show increases in melting point for duplexes with RNA target strands of up to 7.6 °C. The weakly pairing TT dimers are replaced with locked 2′-deoxy-5-(thioalkynyl)uridine residues via automated synthesis.

Graphical abstract: Intrastrand locks increase duplex stability and base pairing selectivity

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2011
Accepted
06 Aug 2011
First published
24 Aug 2011

Chem. Commun., 2011,47, 10824-10826

Intrastrand locks increase duplex stability and base pairing selectivity

C. Prestinari and C. Richert, Chem. Commun., 2011, 47, 10824 DOI: 10.1039/C1CC14008F

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