Synthesis of tert-butyl peresters from aldehydes by Bu4NI-catalyzed metal-free oxidation and its combination with the Kharasch–Sosnovsky reaction

Abstract

A new tert-butyl peresters synthesis directly from aldehydes and TBHP was developed viaBu₄NI-catalyzed aldehyde C−H oxidation. Mechanistic studies suggest that the protocol proceeds via a radical process. Combining the method with the Kharasch–Sosnovsky reaction offers a practical approach for the synthesis of allylic esters from simple aldehydes and alkenesvia a two-step one-pot procedure.