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Issue 36, 2011
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Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins

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Abstract

The chiral N-heterocyclic carbene bearing a proximal hydroxy group derived from L-pyroglutamic acid was found to be an efficient catalyst for the [3+2] annulation of enals and isatins to give the corresponding spirocyclic oxindolo-γ-butyrolactones in good yield with good diastereo- and enantioselectivities.

Graphical abstract: Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins

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Article information


Submitted
28 Jun 2011
Accepted
25 Jul 2011
First published
09 Aug 2011

Chem. Commun., 2011,47, 10136-10138
Article type
Communication

Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins

L. Sun, L. Shen and S. Ye, Chem. Commun., 2011, 47, 10136
DOI: 10.1039/C1CC13860J

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