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Issue 32, 2011
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The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

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Abstract

The synthesis of selenium analogues of de-O-sulfonated ponkoranol, a naturally occurring sulfonium-ion glucosidase inhibitor isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against two recombinant intestinal enzymes maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are described.

Graphical abstract: The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

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Publication details

The article was received on 24 May 2011, accepted on 28 Jun 2011 and first published on 13 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13052H
Chem. Commun., 2011,47, 9134-9136

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    The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

    R. Eskandari, K. Jones, D. R. Rose and B. M. Pinto, Chem. Commun., 2011, 47, 9134
    DOI: 10.1039/C1CC13052H

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