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Issue 26, 2011
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Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

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Abstract

We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.

Graphical abstract: Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

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Publication details

The article was received on 07 Apr 2011, accepted on 17 May 2011 and first published on 01 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC11962A
Chem. Commun., 2011,47, 7488-7490

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    Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

    K. K. Ghosh, H. Ha, N. Kang, Y. Chandran and Y. Chang, Chem. Commun., 2011, 47, 7488
    DOI: 10.1039/C1CC11962A

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