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Issue 26, 2011
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Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

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Abstract

We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.

Graphical abstract: Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

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Article information


Submitted
07 Apr 2011
Accepted
17 May 2011
First published
01 Jun 2011

Chem. Commun., 2011,47, 7488-7490
Article type
Communication

Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

K. K. Ghosh, H. Ha, N. Kang, Y. Chandran and Y. Chang, Chem. Commun., 2011, 47, 7488
DOI: 10.1039/C1CC11962A

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