Issue 26, 2011
From the journal:

Chemical Communications

Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy†

Yosuke Amemiya,ab   Yui Furunaga,a   Keisuke Iida,a   Masayuki Tera,a   Kazuo Nagasawa,a   Kazunori Ikebukuroa  and  Chikashi Nakamura*ab  

* Corresponding authors

a Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan

b BioMedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki 305-8562, Japan
E-mail: Chikashi-nakamura@aist.go.jp
Fax: +81-29-861-3049
Tel: +81-29-861-2445

Abstract

The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex.

Graphical abstract: Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy

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Article information

DOI
https://doi.org/10.1039/C0CC05781A
Article type
Communication
Submitted
24 Dec 2010
Accepted
11 Apr 2011
First published
05 May 2011

Chem. Commun., 2011,47, 7485-7487

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Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy

Y. Amemiya, Y. Furunaga, K. Iida, M. Tera, K. Nagasawa, K. Ikebukuro and C. Nakamura, Chem. Commun., 2011, 47, 7485 DOI: 10.1039/C0CC05781A

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