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Issue 23, 2011
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Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions

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Abstract

An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by 19F-NMR.

Graphical abstract: Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions

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Publication details

The article was received on 18 Mar 2011, accepted on 21 Apr 2011 and first published on 12 May 2011


Article type: Communication
DOI: 10.1039/C1CC11579K
Chem. Commun., 2011,47, 6647-6649

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    Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions

    M. Fischer, H. Kählig and W. Schmid, Chem. Commun., 2011, 47, 6647
    DOI: 10.1039/C1CC11579K

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