Issue 23, 2011
From the journal:

Chemical Communications

Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea†

Tao Zhang,ab   Liang Cheng,a   Shahid Hameed,ac   Li Liu,*a   Dong Wanga  and  Yong-Jun Chen*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: lliu@iccas.ac.cn
Fax: +8610 62554449
Tel: +8610 62554614

b Graduate School of Chinese Academy of Sciences, Beijing 100049, China

c Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan

Abstract

A highly enantioselective Michael addition of 2-oxindoles (1) to vinyl selenone (2) in RTILs catalyzed by a Cinchona alkaloid-based thiourea has been developed in high yields (80–91%) with excellent enantioselectivities (up to 95% ee).

Graphical abstract: Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea

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Article information

DOI
https://doi.org/10.1039/C1CC10880H
Article type
Communication
Submitted
15 Feb 2011
Accepted
14 Mar 2011
First published
04 Apr 2011

Chem. Commun., 2011,47, 6644-6646

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Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea

T. Zhang, L. Cheng, S. Hameed, L. Liu, D. Wang and Y. Chen, Chem. Commun., 2011, 47, 6644 DOI: 10.1039/C1CC10880H

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