Issue 19, 2011
From the journal:

Chemical Communications

Diversity-oriented approach to 1,2-dihydroisoquinolin-3(4H)-imines viacopper(i)-catalyzed reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide and amine†‡

Zhiyuan Chen,a   Chao Ye,a   Liang Gaoa  and  Jie Wu*b  

* Corresponding authors

a Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

b Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
E-mail: jie_wu@fudan.edu.cn
Fax: 86 21 6564 1740
Tel: 8621 6510 2412

Abstract

A three-component reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide, and amine catalyzed by copper(I) chloride (5 mol%), in the presence of triethylamine, under mild conditions is described. This transformation proceeds efficiently to generate 1,2-dihydroisoquinolin-3(4H)-imines in good to excellent yields.

Graphical abstract: Diversity-oriented approach to 1,2-dihydroisoquinolin-3(4H)-imines viacopper(i)-catalyzed reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide and amine

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Article information

DOI
https://doi.org/10.1039/C1CC11176K
Article type
Communication
Submitted
28 Feb 2011
Accepted
25 Mar 2011
First published
11 Apr 2011

Chem. Commun., 2011,47, 5623-5625

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Diversity-oriented approach to 1,2-dihydroisoquinolin-3(4H)-imines viacopper(I)-catalyzed reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide and amine

Z. Chen, C. Ye, L. Gao and J. Wu, Chem. Commun., 2011, 47, 5623 DOI: 10.1039/C1CC11176K

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