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Issue 7, 2011
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Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids

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Abstract

Covering: up to February 2011

The pyrrole-2-aminoimidazole (P-2-AI) alkaloids are a growing family of marine alkaloids, now numbering well over 150 members, with high topographical and biological information content. Their intriguing structural complexity, rich and compact stereochemical content, high N to C ratio (∼1 : 2), and increasingly studied biological activities are attracting a growing number of researchers from numerous disciplines world-wide. This review surveys advances in this area with a focus on the structural diversity, biosynthetic hypotheses with increasing, but still rare, verifying experimental studies, asymmetric syntheses, and biological studies, including cellular target receptor isolation studies, of this stimulating and exciting alkaloid family.

Graphical abstract: Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids

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Article information


Submitted
06 Jul 2010
First published
09 May 2011

Nat. Prod. Rep., 2011,28, 1229-1260
Article type
Review Article

Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids

A. Al-Mourabit, M. A. Zancanella, S. Tilvi and D. Romo, Nat. Prod. Rep., 2011, 28, 1229
DOI: 10.1039/C0NP00013B

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