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Issue 7, 2011
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Anticancer compounds derived from fungal endophytes: their importance and future challenges

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Abstract

Covering: 1990 to 2010

This is a review of anticancer agents isolated from endophytic fungi from 1990–2010. Endophytic fungi are defined as fungi that live asymptomatically within the tissues of higher plants. The designation ‘anticancer’ is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines. Many of the compounds reported here were isolated exclusively from endophytes in culture, while other compounds had been previously reported as chemical constituents of higher plants. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity, or as an alternative source of compounds originally isolated from higher plants. Endophytes represent a dependable source of specific secondary metabolites, and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.

Graphical abstract: Anticancer compounds derived from fungal endophytes: their importance and future challenges

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Article information


Submitted
01 Feb 2011
First published
01 Apr 2011

Nat. Prod. Rep., 2011,28, 1208-1228
Article type
Review Article

Anticancer compounds derived from fungal endophytes: their importance and future challenges

R. N. Kharwar, A. Mishra, S. K. Gond, A. Stierle and D. Stierle, Nat. Prod. Rep., 2011, 28, 1208
DOI: 10.1039/C1NP00008J

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