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Issue 4, 2011
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Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

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Abstract

The syntheses, characterisation and biological activities (IC50; DNA binding) of four mononuclear Pt oxazoline complexes are reported. These materials are the compounds cis-[PtCl2(NH3)(Etox-κ1N)] (1: Etox = 2-ethyl-2-oxazoline), [PtCl2(anilox-κ2N,N′)] (2: anilox = 4,4-dimethyl-2-[o-anilinyl]-2-oxazoline), cis-[PtCl2(Etox-κ1N)2] (3) and [PtCl(pyox-κ3N,N′,N′)] (4: pyoxH = pyridine-2-carboxyanil-[o-{4,4-dimethyl-2-oxazolinyl}-ide]) and all four are shown to have slightly lower cytotoxicities in vitro when compared to cisplatin against the A2780 ovarian cancer cell line. These new materials all appear to be bio-active via the formation of DNA adducts. Complexes 1 and 2 have been further characterised in the solid-state by X-ray diffraction methods.

Graphical abstract: Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

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Publication details

The article was received on 10 Nov 2010, accepted on 14 Dec 2010 and first published on 24 Jan 2011


Article type: Concise Article
DOI: 10.1039/C0MD00211A
Med. Chem. Commun., 2011,2, 274-277

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    Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

    P. N. Yadav, R. E. Beveridge, J. Blay, A. R. Boyd, M. W. Chojnacka, A. Decken, A. A. Deshpande, M. G. Gardiner, T. W. Hambley, M. J. Hughes, L. Jolly, J. A. Lavangie, T. D. MacInnis, S. A. McFarland, E. J. New and R. A. Gossage, Med. Chem. Commun., 2011, 2, 274
    DOI: 10.1039/C0MD00211A

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