Issue 4, 2011
From the journal:

MedChemComm

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model†

Juyoun Jin,‡b   Woo Sirl Lee,‡a   Kyeung Min Joo,‡c   Kaustabh K. Maiti,a   Goutam Biswas,a   Wanil Kim,d   Kyong-Tai Kim,d   Se Jeong Lee,b   Kang-Ho Kim,b   Do-Hyun Nam*b  and  Sung-Kee Chung*a  

* Corresponding authors

a Department of Chemistry, Pohang University of Science and Technology, Pohang, Korea
E-mail: skchung@postech.ac.kr
Fax: +82-54-279-3399

b Department of Neurosurgery and Cancer Stem Cell Research Center, Samsung Medical Center and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea
E-mail: nsnam@skku.edu

c Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea

d Department of Life Science, Pohang University of Science and Technology, Pohang, Korea

Abstract

The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.

Graphical abstract: Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

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Article information

DOI
https://doi.org/10.1039/C0MD00235F
Article type
Concise Article
Submitted
26 Nov 2010
Accepted
16 Jan 2011
First published
11 Feb 2011

Med. Chem. Commun., 2011,2, 270-273

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Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

J. Jin, W. S. Lee, K. M. Joo, K. K. Maiti, G. Biswas, W. Kim, K. Kim, S. J. Lee, K. Kim, D. Nam and S. Chung, Med. Chem. Commun., 2011, 2, 270 DOI: 10.1039/C0MD00235F

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