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Issue 33, 2011
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SNARE derived peptide mimic inducing membrane fusion

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Abstract

SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

Graphical abstract: SNARE derived peptide mimic inducing membrane fusion

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Publication details

The article was received on 16 May 2011, accepted on 28 Jun 2011 and first published on 20 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC12879E
Chem. Commun., 2011,47, 9405-9407

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    SNARE derived peptide mimic inducing membrane fusion

    K. Meyenberg, A. S. Lygina, G. van den Bogaart, R. Jahn and U. Diederichsen, Chem. Commun., 2011, 47, 9405
    DOI: 10.1039/C1CC12879E

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