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Issue 15, 2011
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DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker

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Abstract

Nucleic acid templated reactions have attracted significant attention for nucleic acid sensing. Herein we report a general design which extends the potential of nucleic acid templated reactions to unleash the function of a broad diversity of small molecules such as a transcription factor agonist, a cytotoxic or a fluorophore.

Graphical abstract: DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker

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Article information


Submitted
12 Jan 2011
Accepted
11 Feb 2011
First published
03 Mar 2011

Chem. Commun., 2011,47, 4364-4366
Article type
Communication

DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker

K. Gorska, A. Manicardi, S. Barluenga and N. Winssinger, Chem. Commun., 2011, 47, 4364
DOI: 10.1039/C1CC10222B

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