Issue 31, 2010
From the journal:

Chemical Communications

Label-free DNA detection platform based on atomic force microscopy visualisation: characterising the molecular-recognition-triggered conformational changes of an immobilised receptoroligonucleotideprobe†

Koji Nakano,*a   Hirokazu Yamanouchi,a   Hisao Yoshinaga,a   Nobuaki Soha  and  Toshihiko Imatoa  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
E-mail: nakano@cstf.kyushu-u.ac.jp

Abstract

Using atomic microscopy imaging, probe DNA sequence self-assemblies developed on Si(100) substrates undergo a conformational transition from an extended stem-loop structure to a double helix; such assemblies readily report on DNA molecular recognition events and should be suitable as a label-free, DNA hybridisation assay platform.

Graphical abstract: Label-free DNA detection platform based on atomic force microscopy visualisation: characterising the molecular-recognition-triggered conformational changes of an immobilised receptor oligonucleotide probe

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Article information

DOI
https://doi.org/10.1039/C002642E
Article type
Communication
Submitted
08 Feb 2010
Accepted
18 Jun 2010
First published
02 Jul 2010

Chem. Commun., 2010,46, 5683-5685

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Label-free DNA detection platform based on atomic force microscopy visualisation: characterising the molecular-recognition-triggered conformational changes of an immobilised receptor oligonucleotide probe

K. Nakano, H. Yamanouchi, H. Yoshinaga, N. Soh and T. Imato, Chem. Commun., 2010, 46, 5683 DOI: 10.1039/C002642E

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