Issue 31, 2010
From the journal:

Chemical Communications

Inhibition of twisting of a green fluorescent protein-like chromophore by metal complexation†

Anthony Baldridge,a   Kyril M. Solntsev,*a   Charles Song,a   Tatsuro Tanioka,a   Janusz Kowalik,*a   Kenneth Hardcastleb  and  Laren M. Tolbert*a  

* Corresponding authors

a School of Chemistry and Biochemistry, 901 Atlantic Dr, Georgia Institute of Technology, Atlanta, USA
E-mail: solntsev@gatech.edu, jk8@mail.gatech.edu, tolbert@chemistry.gatech.edu
Fax: +1 404 8947452
Tel: +1 404 3853117

b Department of Chemistry, Emory University, 1515 Dickey Dr, Atlanta, USA

Abstract

Substitution of a pyridyl for the hydroxyphenyl moiety in the Green Fluorescent Protein analog p-hydroxybenzylidene-dimethylimidiazolinone produces a chromophore which “turns on” fluorescence in the presence of Zn2+ or Cd2+ ions. Such a phenomenon provides “proof of principle” for using GFP chromophores in a variety of sensing applications.

Graphical abstract: Inhibition of twisting of a green fluorescent protein-like chromophore by metal complexation

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Article information

DOI
https://doi.org/10.1039/B927313A
Article type
Communication
Submitted
05 Jan 2010
Accepted
07 Jun 2010
First published
21 Jun 2010

Chem. Commun., 2010,46, 5686-5688

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Inhibition of twisting of a green fluorescent protein-like chromophore by metal complexation

A. Baldridge, K. M. Solntsev, C. Song, T. Tanioka, J. Kowalik, K. Hardcastle and L. M. Tolbert, Chem. Commun., 2010, 46, 5686 DOI: 10.1039/B927313A

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