Jump to main content
Jump to site search

Issue 18, 2010
Previous Article Next Article

Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites

Author affiliations

Abstract

Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phosphoramidates.

Graphical abstract: Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites

Back to tab navigation

Supplementary files

Article information


Submitted
21 Dec 2009
Accepted
19 Feb 2010
First published
11 Mar 2010

Chem. Commun., 2010,46, 3176-3178
Article type
Communication

Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites

V. Böhrsch, R. Serwa, P. Majkut, E. Krause and C. P. R. Hackenberger, Chem. Commun., 2010, 46, 3176
DOI: 10.1039/B926818A

Social activity

Search articles by author

Spotlight

Advertisements