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Issue 18, 2010
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Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites

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Abstract

Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phosphoramidates.

Graphical abstract: Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites

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Publication details

The article was received on 21 Dec 2009, accepted on 19 Feb 2010 and first published on 11 Mar 2010


Article type: Communication
DOI: 10.1039/B926818A
Chem. Commun., 2010,46, 3176-3178

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    Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites

    V. Böhrsch, R. Serwa, P. Majkut, E. Krause and C. P. R. Hackenberger, Chem. Commun., 2010, 46, 3176
    DOI: 10.1039/B926818A

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