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Issue 16, 2010
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Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe

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Abstract

An optical interface has been designed to maximise the sensitivity and spatial resolution required when Raman spectrometry is used to monitor a reaction in a micro-reactor, revealing advantages over a conventional commercial probe. A miniature aspheric lens was shown to be better than microscope objectives to focus the probing laser beam onto the sample. The diameters of the exciting and collection optical fibres were also shown to have a significant influence on sensitivity and the signal-to-background ratio, with 62.5 µm diameter 0.28 numerical aperture (NA) fibres found to be best for analysis of liquids in the 150 µm deep channel in the micro-reactor used. With a spectral measurement time of 2 s, it was shown that the probe could monitor the progress of an esterification reaction in real time and quickly optimise the reagent flow rates. The fast response time revealed features related to short-term pump instabilities and micro-reactor rheology effects that would not have been identified without rapid real-time measurements.

Graphical abstract: Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe

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Supplementary files

Article information


Submitted
15 Mar 2010
Accepted
25 May 2010
First published
14 Jun 2010

Lab Chip, 2010,10, 2101-2107
Article type
Paper

Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe

S. Mozharov, A. Nordon, J. M. Girkin and D. Littlejohn, Lab Chip, 2010, 10, 2101 DOI: 10.1039/C004248J

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