Issue 20, 2009
From the journal:

Organic & Biomolecular Chemistry

Inhibition of the exo-β-d-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue†

Benjamin Pluvinage,b   Mariana G. Ghinet,c   Ryszard Brzezinski,c   Alisdair B. Borastonb  and  Keith A. Stubbs*a  

* Corresponding authors

a Chemistry M313, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA, Australia
E-mail: kstubbs@cyllene.uwa.edu.au
Tel: +61 8 6488 2725

b Biochemistry and Microbiology, University of Victoria, PO Box 3055 STN CSC, Victoria, BC, Canada

c Centre d’Étude et de Valorisation de la Diversité Microbienne, Département de Biologie, Université de Sherbrooke, Sherbrooke, QC, Canada

Abstract

The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-β-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.

Graphical abstract: Inhibition of the exo-β-d-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue

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Article information

DOI
https://doi.org/10.1039/B913235J
Article type
Communication
Submitted
06 Jul 2009
Accepted
04 Aug 2009
First published
14 Aug 2009

Org. Biomol. Chem., 2009,7, 4169-4172

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Inhibition of the exo-β-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue

B. Pluvinage, M. G. Ghinet, R. Brzezinski, A. B. Boraston and K. A. Stubbs, Org. Biomol. Chem., 2009, 7, 4169 DOI: 10.1039/B913235J

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