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The regioselective 1,3-dipolar cycloaddition of α-bromo-pentafluorophenyl vinylsulfonate with nitrile oxides has been used to rapidly access a range of 3,5-isoxazoles which could be converted directly to their corresponding sulfonamides.

Graphical abstract: 3,5-Isoxazoles from α-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulfonamides

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