Issue 21, 2009
From the journal:

Organic & Biomolecular Chemistry

Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate†

Jian-Wu Xie,*ab   Zheng Wang,a   Wei-Jun Yang,a   Li-Chun Konga  and  Dong-Cheng Xua  

* Corresponding authors

a Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China

b Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Zhejiang Normal University, Jinhua, China
E-mail: xiejw@zjnu.cn
Fax: +86 579 82282610

Abstract

The one-pot synthesis of multisubstituted pyrazole derivatives was achieved viacatalyst-free 1,3-dipolar cycloaddition of ethyl diazoacetate and nitroalkenes as the key step and elimination of the leaving group (NO2 or Br) followed by intramolecular proton transfer with satisfactory yields.

Graphical abstract: Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate

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Article information

DOI
https://doi.org/10.1039/B915231H
Article type
Communication
Submitted
27 Jul 2009
Accepted
12 Aug 2009
First published
28 Aug 2009

Org. Biomol. Chem., 2009,7, 4352-4354

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Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate

J. Xie, Z. Wang, W. Yang, L. Kong and D. Xu, Org. Biomol. Chem., 2009, 7, 4352 DOI: 10.1039/B915231H

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