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Issue 28, 2009
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Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

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Abstract

A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral γ-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.

Graphical abstract: Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

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Article information


Submitted
11 Mar 2009
Accepted
19 May 2009
First published
10 Jun 2009

Chem. Commun., 2009, 4251-4253
Article type
Communication

Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

H. Lu, X. Wang, C. Yao, J. Zhang, H. Wu and W. Xiao, Chem. Commun., 2009, 4251
DOI: 10.1039/B905033G

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