Jump to main content
Jump to site search

Issue 10, 2009
Previous Article Next Article

GFP: from jellyfish to the Nobel prize and beyond

Author affiliations

Abstract

On December 10, 2008 Osamu Shimomura, Martin Chalfie and Roger Tsien were awarded the Nobel Prize in Chemistry for “the discovery and development of the green fluorescent protein, GFP”. The path taken by this jellyfish protein to become one of the most useful tools in modern science and medicine is described. Osamu Shimomura painstakingly isolated GFP from hundreds of thousands of jellyfish, characterized the chromophore and elucidated the mechanism of Aequorean bioluminescence. Martin Chalfie expressed the protein in E. coli and C. elegans, and Roger Tsien developed a palette of fluorescent proteins that could be used in a myriad of applications.

Graphical abstract: GFP: from jellyfish to the Nobel prize and beyond

Back to tab navigation

Article information


First published
15 Jun 2009

Chem. Soc. Rev., 2009,38, 2823-2832
Article type
Highlight

GFP: from jellyfish to the Nobel prize and beyond

M. Zimmer, Chem. Soc. Rev., 2009, 38, 2823
DOI: 10.1039/B904023D

Social activity

Search articles by author

Spotlight

Advertisements