Issue 10, 2009

GFP: from jellyfish to the Nobel prize and beyond

Abstract

On December 10, 2008 Osamu Shimomura, Martin Chalfie and Roger Tsien were awarded the Nobel Prize in Chemistry for “the discovery and development of the green fluorescent protein, GFP”. The path taken by this jellyfish protein to become one of the most useful tools in modern science and medicine is described. Osamu Shimomura painstakingly isolated GFP from hundreds of thousands of jellyfish, characterized the chromophore and elucidated the mechanism of Aequorean bioluminescence. Martin Chalfie expressed the protein in E. coli and C. elegans, and Roger Tsien developed a palette of fluorescent proteins that could be used in a myriad of applications.

Graphical abstract: GFP: from jellyfish to the Nobel prize and beyond

Article information

Article type
Highlight
First published
15 Jun 2009

Chem. Soc. Rev., 2009,38, 2823-2832

GFP: from jellyfish to the Nobel prize and beyond

M. Zimmer, Chem. Soc. Rev., 2009, 38, 2823 DOI: 10.1039/B904023D

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