Potent HIV-1protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein–ligand X-ray studies†
Abstract
Recently, we designed a series of novel
* Corresponding authors
a
Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, USA
E-mail:
akghosh@purdue.edu
Fax: +1 765 4961612
Tel: +1 765 4945323
b Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, USA
c Kumamoto University School of Medicine,
d Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, USA
Recently, we designed a series of novel
A. K. Ghosh, S. Gemma, J. Takayama, A. Baldridge, S. Leshchenko-Yashchuk, H. B. Miller, Y. Wang, A. Y. Kovalevsky, Y. Koh, I. T. Weber and H. Mitsuya, Org. Biomol. Chem., 2008, 6, 3703 DOI: 10.1039/B809178A
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