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Issue 12, 2008
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Primary amino acids: privileged catalysts in enantioselective organocatalysis

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Abstract

Despite the recent spectacular advances in asymmetric organocatalysis, proline and its analogues have been predominantly employed as organocatalysts in reactions utilizing enamine intermediates. Recent studies of enantioselective organocatalytic reactions promoted by primary amino acids and their derivatives are described in this account. The primary amino functions, rather than the secondary pyrrolidine moiety, have been shown to provide unique reactivity and stereoselectivity in asymmetric aldol and Mannich reactions.

Graphical abstract: Primary amino acids: privileged catalysts in enantioselective organocatalysis

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Publication details

The article was received on 22 Feb 2008, accepted on 14 Mar 2008 and first published on 21 Apr 2008


Article type: Emerging Area
DOI: 10.1039/B803116A
Citation: Org. Biomol. Chem., 2008,6, 2047-2053
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    Primary amino acids: privileged catalysts in enantioselective organocatalysis

    L. Xu and Y. Lu, Org. Biomol. Chem., 2008, 6, 2047
    DOI: 10.1039/B803116A

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