Issue 30, 2008
From the journal:

Chemical Communications

Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes†

Craig D. Campbell,a   Nicolas Duguet,a   Katherine A. Gallagher,a   Jennifer E. Thomson,a   Anita G. Lindsay,b   AnnMarie C. O’Donoghueb  and  Andrew D. Smith*a  

* Corresponding authors

a EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, UK
E-mail: ads10@st-andrews.ac.uk

b Department of Chemistry, University of Durham, University Science Laboratories, South Road, Durham, UK

Abstract

Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (±)-4-phenoxycarbonylazlactones in good isolated yields (66–84%) from the corresponding N-p-anisoyl amino acids.

Graphical abstract: Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes

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Article information

DOI
https://doi.org/10.1039/B806816J
Article type
Communication
Submitted
22 Apr 2008
Accepted
20 Jun 2008
First published
07 Jul 2008

Chem. Commun., 2008, 3528-3530

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Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes

C. D. Campbell, N. Duguet, K. A. Gallagher, J. E. Thomson, A. G. Lindsay, A. C. O’Donoghue and A. D. Smith, Chem. Commun., 2008, 3528 DOI: 10.1039/B806816J

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