Issue 30, 2008
From the journal:

Chemical Communications

Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations†

Kateřina Čapková,a   Mark S. Hixon,‡a   Laura A. McAllistera  and  Kim D. Janda*ab  

* Corresponding authors

a Departments of Chemistry and Immunology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA
E-mail: kdjanda@scripps.edu
Fax: +1 858 784-2516
Tel: +1 858 784-2595

b Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA

Abstract

The development of a sensitive, yet reliable assay for the analysis of botulinum neurotoxin A (BoNT/A) inhibitors is described; using this assay a new protease inhibitor was characterized and found to be one of the most potent inhibitors reported to date.

Graphical abstract: Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations

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Article information

DOI
https://doi.org/10.1039/B808305C
Article type
Communication
Submitted
16 May 2008
Accepted
18 Jun 2008
First published
03 Jul 2008

Chem. Commun., 2008, 3525-3527

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Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations

K. Čapková, M. S. Hixon, L. A. McAllister and K. D. Janda, Chem. Commun., 2008, 3525 DOI: 10.1039/B808305C

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