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Issue 29, 2008
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Double decarboxylative Claisen rearrangement reactions: microwave-assisted de novo synthesis of pyridines

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Abstract

Microwave-assisted double decarboxylative Claisen rearrangement of bis(allyl) 2-tosylmalonates provides substituted 1,6-heptadienes, which may be alkylated, and then converted into pyridines by ozonolysis followed by reaction with ammonia generated in situ under microwave conditions.

Graphical abstract: Double decarboxylative Claisen rearrangement reactions: microwave-assisted de novo synthesis of pyridines

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Publication details

The article was received on 26 Mar 2008, accepted on 15 Apr 2008 and first published on 14 May 2008


Article type: Communication
DOI: 10.1039/B805078C
Chem. Commun., 2008, 3408-3410

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    Double decarboxylative Claisen rearrangement reactions: microwave-assisted de novo synthesis of pyridines

    D. Craig, F. Paina and S. C. Smith, Chem. Commun., 2008, 3408
    DOI: 10.1039/B805078C

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