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Issue 7, 2008
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Site isolated base and acid catalyzed azaspirocyclization cascades

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Abstract

A one-pot, site isolated base (PS-BEMP) and acid (Si-TsOH) catalyzed cyclization cascade to azaspirocyclic molecules is reported; the reaction is simple to perform, atom efficient (water is the only byproduct) and broad in its scope to a diverse range of azaspirocyclic products.

Graphical abstract: Site isolated base and acid catalyzed azaspirocyclization cascades

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Supplementary files

Article information


Submitted
29 Oct 2007
Accepted
14 Dec 2007
First published
03 Jan 2008

Chem. Commun., 2008, 832-834
Article type
Communication

Site isolated base and acid catalyzed azaspirocyclization cascades

A. W. Pilling, J. Böhmer and D. J. Dixon, Chem. Commun., 2008, 832
DOI: 10.1039/B716568D

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