Issue 14, 2007
From the journal:

Organic & Biomolecular Chemistry

Complex formation between cationic β-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion†

Masato Ikeda,a   Jusaku Minari,b   Naohiko Shimada,b   Munenori Numata,a   Kazuo Sakuraib  and  Seiji Shinkai*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka, Japan
E-mail: seijitcm@mbox.nc.kyushu-u.ac.jp

b Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, Hibikino 1-1, Wakamatsu-ku, Kitakyushu, Fukuoka, Japan

Abstract

A cationic polysaccharide bearing a β-1,3-glucan main-chain structure (CUR-N+) forms a complex with a hetero-sequence oligonucleotide, that is, a CpG ODN, and facilitates the transportation of the resultant complex into a murine macrophage-like cell J774.A1, which induces an efficient secretion of a cytokine (IL-12) as compared with that induced by conventional carriers such as poly(ethyleneimine) (PEI) and poly(L-lysine) (PLL).

Graphical abstract: Complex formation between cationic β-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion

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Article information

DOI
https://doi.org/10.1039/B705997C
Article type
Paper
Submitted
20 Apr 2007
Accepted
21 May 2007
First published
07 Jun 2007

Org. Biomol. Chem., 2007,5, 2219-2224

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Complex formation between cationic β-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion

M. Ikeda, J. Minari, N. Shimada, M. Numata, K. Sakurai and S. Shinkai, Org. Biomol. Chem., 2007, 5, 2219 DOI: 10.1039/B705997C

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