A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides

Abstract

A strategy for the synthesis of 2,3-disubstituted indole derivatives based on an intramolecular carbopalladation–anion capture cascade has been developed, wherein construction of the pyrrole ring and functionalisation of the indole C2 and C3 positions were achieved by extensive use of palladium(0)-catalysed coupling reactions.