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Abstract | Cited by

Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir and abacavir, were efficiently synthesized from a common intermediate 4. Their antitumor and antiviral activities were evaluated and the results indicate norabacavir showed comparable anti-HIV activity to that of abacavir.

Graphical abstract: Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

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