Issue 8, 2007
From the journal:

Organic & Biomolecular Chemistry

Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base–zinc complex†

Quan Wang,a   Bangzhi Zhang,ab   Guowen Hu,a   Chao Chen,a   Qinyang Zhaoa  and  Rui Wang*ab  

* Corresponding authors

a Department of Biochemistry and Molecular Biology, School of Life Sciences, and State key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, China
E-mail: wangrui@lzu.edu.cn
Fax: +86 931 8912567
Tel: +86 931 8911255

b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China

Abstract

The evaluation of a chiral Schiff base ligand in the zinc-catalyzed asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones is reported (with up to 83% enantioselectivity and up to 88% isolated yield).

Graphical abstract: Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base–zinc complex

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Article information

DOI
https://doi.org/10.1039/B702069D
Article type
Communication
Submitted
09 Feb 2007
Accepted
26 Feb 2007
First published
09 Mar 2007

Org. Biomol. Chem., 2007,5, 1161-1163

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Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base–zinc complex

Q. Wang, B. Zhang, G. Hu, C. Chen, Q. Zhao and R. Wang, Org. Biomol. Chem., 2007, 5, 1161 DOI: 10.1039/B702069D

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